Sodium Periodate

Sodium Periodate
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Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. It may also be regarded as the sodium salt of periodic acid. Like many periodates, it can exist in two different forms: sodium metaperiodate and sodium orthoperiodate. Both salts are useful oxidising agents.
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What is Sodium Periodate?

 

 

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. It may also be regarded as the sodium salt of periodic acid. Like many periodates, it can exist in two different forms: Sodium metaperiodate and sodium orthoperiodate. Both salts are useful oxidising agents.

 

What Is The Use Of Sodium Periodate?

 

Sodium periodate, white crystalline powder, soluble in water, acetic acid, hydrochloric acid, sulfuric acid, nitric acid, insoluble in ethanol. Sodium periodate is a white quadrangular crystal that can be dissolved in water and acid. It contains trace impurities such as free acid, chloride, bromide, sulfate and heavy metal. It can be refined by recrystallization from aqueous solution. This kind of material has strong oxidation performance. Although it does not burn itself, under certain conditions, substances that are subject to friction, vibration and impact, high heat or acid and alkali can decompose, burn and explode when they are exposed to moisture, organic substances, reducing agents and substances that are incompatible with nature. Sodium periodate has two main uses in organic synthesis: as oxidant and catalyst. Due to the solubility, the oxidation reaction of sodium periodate is generally carried out in water. Because many organic chemicalbooks are insoluble in water, it is necessary to use cosolvent. When there is a phase transfer catalyst or sodium periodate is loaded on an inert carrier, the oxidation reaction can also be carried out in a two-phase system.

Sodium periodate has two main uses in organic synthesis: on the one hand, it is used as an oxidant; On the other hand, it is used as a catalyst. The oxidation reaction of sodium periodate takes place in water, but for organic matter, it is insoluble in water, so the cosolvent should be used. When there is a phase transfer catalyst composed of quaternary ammonium salt in the two-phase solution, or there is an inert carrier on the surface of the oxidant, the oxidation reaction can also occur.

Sodium periodate even breaks the C=C double bond and oxidizes it to carbonyl compounds. It is called the famous Lemieux-Johnson reagent when combined with OsO4 to oxidize alkenes.

Selective oxidation of sulfide to sulfoxide is a very important reaction, because sulfoxide is a very important intermediate in organic synthesis. It can react with sodium periodate in methanol solution at 0 oC. Sulfide will be oxidized to sulfone at high temperature or by adding excessive sodium periodate.

 

 
 
Short Description About Sodium Periodate Market
Sodium Periodate

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. It may also be regarded as the sodium salt of periodic acid. Like many periodates it can exist in two different forms: sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared. Both salts are useful oxidising agents.

Due to the COVID-19 pandemic, the global Sodium Periodate market size is estimated to be worth USD million in 2022 and is forecast to a readjusted size of USD million by 2028 with a CAGR of Percent during the forecast period 2022-2028. Fully considering the economic change by this health crisis, Sodium Metaperiodate accounting for Percent of the Sodium Periodate global market in 2021, is projected to value USD million by 2028, growing at a revised Percent CAGR from 2022 to 2028. While Pharmaceutical Industry segment is altered to an Percent CAGR throughout this forecast period.

North America Sodium Periodate market is estimated at USD million in 2021, while Europe is forecast to reach USD million by 2028. The proportion of the North America is Percent in 2021, while Europe percentage is Percent, and it is predicted that Europe share will reach Percent in 2028, trailing a CAGR of Percent through the analysis period 2022-2028. As for the Asia, the notable markets are Japan and South Korea, CAGR is Percent and Percent respectively for the next 6-year period.

The global major manufacturers of Sodium Periodate include William Blythe, Henan Wanxiang Chemical, Jiangxi Shengdian S&T, Qingdao Tocean Iodine Products, Jiodine Chemical (Qingdao), Zibo Wankang Pharmaceutical Chemical, Shandong Boyuan Pharmaceutical & Chemical, Jinan FuFang Chemical and Jindian Chemical, etc. In terms of revenue, the global 3 largest players have a Percent market share of Sodium Periodate in 2021.

Sodium Periodate

 

A Versatile Oxidizing Agent Of Sodium Periodate
 

Sodium Periodate, also known as sodium periodate, is a powerful oxidizing agent used in various industries, including pharmaceuticals, agrochemicals, and analytical chemistry. Its CAS number is 7790-28-5, and it is widely used due to its versatility and effectiveness in oxidizing organic compounds.

 

Sodium periodate is a white crystalline solid that is soluble in water and alcohol. It is a strong oxidizing agent that can react with a wide range of organic compounds, including alcohols, aldehydes, ketones, and amines. Sodium periodate is a preferred oxidizing agent in the pharmaceutical industry due to its ability to selectively oxidize certain functional groups without affecting other parts of the molecule.

 

Pharmaceutical grade sodium periodate is used in the manufacturing of drugs and drug intermediates, while analytical grade sodium periodate is used in analytical chemistry applications.

 

Sodium periodate is also used in the agrochemical industry as a crop protection agent. It is used to synthesize various herbicides and fungicides that are used to control pests and diseases in crops. Sodium periodate is also used as a bleaching agent in the paper and textile industries.

 

One of the advantages of using sodium periodate is that it is a selective oxidizing agent that can target specific functional groups in organic compounds. This property is useful in drug discovery and development, where chemists need to modify molecules to improve their activity or selectivity. Sodium periodate is also a safe and environmentally friendly oxidizing agent that does not produce harmful byproducts.

 

Effects Of Sodium Periodate On Platelet Functions

 

 

Removal of N-acetylneuraminic acid from the platelet surface causes rapid removal of platelets from the circulation but causes little change in other platelet functions. We have now investigated the effects of sodium periodate which is thought to oxidize the sialic acid of glycoproteins on cell surfaces and has been shown to affect the functions of other cells.

Sodium Periodate (1 to 10 mm) caused aggregation of stirred suspensions of washed platelets from rabbits. Calcium was required in the suspending medium for Sodium Periodate induced aggregation. Aggregation was not accompanied by the release of amine storage granule contents nor by cell lysis. Aggregation induced by Sodium Periodate was not inhibited by creatine phosphate-creatine phosphokinase, by platelet inhibitors that raise platelet cyclic AMP levels such as prostaglandin E1 or methylxanthines, by agents that modify platelet surface--SH groups (N-ethylmaleimide, p-chloromercuribenzene sulfonate), nor by cytochalasin B and/or colchicine which interfere with platelet contractile processes. Drugs such as acetylsalicyclic acid, penicillin G, or cephalothin had no effect on Sodium Periodate induced aggregation.

Sodium Periodate induced aggregation was practically independent of platelet metabolism since it was not affected by low temperatures and was only slightly inhibited by a combination of antimycin and iodoacetate. Periodate treatment enhanced CO2 production by platelets. When rabbit platelets were pretreated, without stirring, with Sodium Periodate (0.01 to 1 mm), they did not aggregate.

They retained their disc shape and granule contents. However, this pretreatment with Sodium Periodate inhibited aggregation induced by ADP and inhibited both aggregation and release induced by collagen, thrombin, arachidonic acid, and the ionophore A23,187. The extent of inhibition corresponded to the concentration of Sodium Periodate used to pretreat the platelets. In contrast, concanavalin A-induced aggregation was unchanged by Sodium Periodate pretreatment.

Pretreatment with Sodium Periodate also diminished the rate of serotonin uptake and decreased the ability of platelets to adhere to collagen-coated surfaces or to the subendothelial structures of the rabbit aorta. Platelets which had been treated with Sodium Periodate and then reinfused into rabbits did not survive, and in this way were similar to platelets from which surface sialic acid had been removed by neuraminidase treatment.

Since Sodium Periodate has been shown to oxidize sialic acid on red cell membranes, it seems probably that alteration of surface sialic acid resulted in recognition of the periodate-treated platelets as "foreign" by the reticuloendothelial system.

 

 
Our Factory

 

The company, located in Yanhai Industrial Park, one of the largest pharmaceutical industrial zones in China, covers an area of 35 acres. Through its three product segments - Guaiacol derivatives, Epichlorohydrin derivatives and Iodine contrast media - Haizhou Pharm offers a portfolio of products and services globally, including Active Pharmaceutical Ingredients (API), Intermediates, fine chemicals and Customs manufacturing service.

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FAQ
 

Q: What does sodium periodate do?

A: Sodium meta-periodate is an oxidizing agent that can be used to create aldehydes on chromatography supports that contain diols. Hydroxyl groups present on adjacent carbon atoms are a common feature in many resins made from polysaccharides, such as beaded agarose, cellulose supports, or cellulosic membranes.

Q: What are the uses of periodate?

A: Periodates are highly selective etchants for certain ruthenium-based oxides. Several staining agents use in microscopy are based around periodate (e.g. periodic acid–Schiff stain and Jones' stain). Periodates have also been used as oxidising agents for use in pyrotechnics.

Q: How to remove sodium periodate?

A: Desalt or dialyze the sample to remove the sodium meta-periodate. Maintain the oxidized sample in an amine-free buffer until the intended experimental reactions with aldehyde groups have been completed.

Q: How do you make sodium periodate?

A: The trisodium dihydrogen periodate is obtained by reacting sodium chlorate and iodine in an aqueous solution to produce the sodium hydrogen iodate, neutralizing the sodium hydrogen iodate by using sodium hydroxide to obtain the sodium iodate and oxidizing the sodium iodate in the sodium hydroxide solution by using the ...

Q: Is periodate an oxidizing agent?

A: Like Ce(IV), periodate is a very strong oxidant that is able to oxidise water to oxygen and can be readily monitored spectrophotometrically at 280 nm, compared with 430 nm for Ce(IV).

Q: What is the function of sodium periodate?

A: Sodium periodate is a chemical compound used in organic chemistry to cleave diols directly, as well as in the oxidative cleavage of alkenes.

Q: What is the difference between sodium periodate and sodium metaperiodate?

A: Sodium metaperiodate is an inorganic chemical compound, and it is a derivative of sodium periodate. The key difference between sodium periodate and sodium metaperiodate is that sodium periodate is a hypovalent compound, whereas sodium metaperiodate is a hypervalent compound.

Q: What are the reactions of periodate?

A: Periodate oxidation is a well-known reaction that leads to specific oxidation of free vicinal hydroxyl groups to aldehydes with internal ring cleavage (Kristiansen et al., 2010), creating polyaldehydes. For the reaction to take place, vicinal hydroxyl groups must be oriented in an equatorial (eq.) -eq. or axial (ax.)

Q: How do you make 0.1 M sodium periodate?

A: 0.1 M Sodium periodate.
Dissolve 21.4 g of sodium periodate R in about 500 mL of water R and dilute to 1000.0 mL with the same solvent. Standardisation. In a stoppered flask, introduce 20.0 mL of the sodium periodate solution and add 5 mL of perchloric acid R. Close the flask and shake.

Q: What is the use of periodate?

A: Uses: Sodium periodate is used to oxidize cellulose and create a biocompatible and biodegradable compound that can be used as suture, as a scaffold for tissue engineering, or for drug delivery.

Q: How to dissolve sodium periodate?

A: Sodium Periodate Solution Dissolve 1.07 g of sodium periodate in water, and add 5 mL of 1m sulfuric acid and sufficient water to produce 100 mL. It should be freshly prepared.

Q: What is the sodium periodate reagent?

A: Sodium periodate is an inorganic salt commonly used as an oxidizing agent for various organic substrates and a co-oxidant in a few other oxidation reactions. The oxidation of sodium periodate takes place in a water medium, but an organic co-solvent is used for organic substrates that are insoluble in water. Application.

Q: What is oxidation with sodium periodate?

A: A ruthenium catalyst bearing a fused π-conjugated imidazo[1,2-a][1,8]naphthyridine-based abnormal N-heterocyclic carbene ligand enables a selective oxidation of C═C bonds in a broad range of substrate to aldehydes and C≡C bonds to α-diketones in an EtOAc/CH3CN/H2O solvent mixture at room temperature.

Q: What is the role of sodium periodate?

A: Sodium periodate is commonly used in the production of human immunoglobulin, which is used to treat autoimmune disorders such as rheumatoid arthritis and multiple sclerosis. It has also been shown to have potential as a fluorescence probe for acidic compounds in water vapor.

Q: What is sodium periodate reagent?

A: Description Sodium periodate is an inorganic salt commonly used as an oxidizing agent for various organic substrates and a co-oxidant in a few other oxidation reactions. The oxidation of sodium periodate takes place in a water medium, but an organic co-solvent is used for organic substrates that are insoluble in water.

Q: What is the periodate oxidation method?

A: Periodate oxidation is a classic reaction in carbohydrate chemistry used to split bonds between vicinal carbons bearing unsubstituted hydroxyl or amino groups (17). As shown in Fig. 1, heparin bonds cleavable by periodate are those of non-sulfated uronic acid residues, i.e., GlcA and IdoA.

Q: Is sodium periodate periodic acid?

A: Sodium periodate is a colorless solid. It reacts with acids to make periodic acid. It breaks down when heated to make sodium iodate and oxygen gas. It is a strong oxidizing agent.

Q: What is sodium periodate oxidative cleavage?

A: General Characteristics Periodic acid or sodium periodate is used to oxidatively cleave 1,2-diols, producing a pair of aldehydes or ketones. Sodium periodate also works as the reoxidant of osmium tetroxide, so these two reagents provide a way to oxidatively cleave alkenes under mild conditions.

Q: How to remove sodium periodate?

A: Desalt or dialyze the sample to remove the sodium meta-periodate. Maintain the oxidized sample in an amine-free buffer until the intended experimental reactions with aldehyde groups have been completed.

Q: What is oxidation with sodium periodate?

A: A ruthenium catalyst bearing a fused π-conjugated imidazo[1,2-a][1,8]naphthyridine-based abnormal N-heterocyclic carbene ligand enables a selective oxidation of C═C bonds in a broad range of substrate to aldehydes and C≡C bonds to α-diketones in an EtOAc/CH3CN/H2O solvent mixture at room temperature.

 

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