Iodixanol

Our Company
The company, located in Yanhai Industrial Park-one of the largest pharmaceutical industrial zones in China-covers an area of 35 acres. Through its three product segments-Guaiacol derivatives, Epichlorohydrin derivatives, and Iodine contrast media-Haizhou Pharm offers a portfolio of products and services globally, including Active Pharmaceutical Ingredients (API), intermediates, fine chemicals, and custom manufacturing services.

GMP Service
With professional contract manufacturing project team and multi-functional workshops, the company is in long-term cooperation with famous global pharmaceutical enterprises, providing contract service under both GMP and none GMP conditions.

Certifications
Haizhou Pharm is ISO9001/14001 and OHSAS18001 approved, and ISO/OHSAS management philosophy deeps into whole process of the company.

Professional Contract Solutions
With professional contract manufacturing project team and multi-functional workshops, the company is in long-term cooperation with famous global pharmaceutical enterprises, providing contract service under both GMP and none GMP conditions.

Iodixanol is in a group of drugs called radiopaque (RAY dee oh payk) contrast agents. Iodixanol contains iodine, a substance that absorbs x-rays. Radiopaque contrast agents are used to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on a CT scan or other radiologic (x-ray) examination.

Iodixanol is injected into a vein through an IV. A healthcare provider will give you this injection just before your radiologic test.

You may be given medication to prevent certain side effects while you are receiving iodixanol.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when iodixanol is injected.

Drink extra fluids before and after your radiologic test. Iodixanol can cause you to get dehydrated, which can lead to dangerous effects on your kidneys. Follow your doctor's instructions about the types and amount of fluids you should drink before and after your test.

Older adults may need special care to avoid becoming dehydrated. Your kidney function may need to be checked after you have received iodixanol.

Iodixanol can interfere with certain medical tests for up to 16 days after you are treated with this medicine. Tell any doctor who treats you that you have recently received iodixanol.

Iodixanol can make radioactive iodine less effective in people with thyroid cancer. This effect can last for up to 8 weeks after you receive iodixanol. Tell your doctor if you are scheduled to be treated with radioactive iodine I-131 or I-123.

Iodixanol is a widely recognized contrast agent used in medical imaging, known by trade names such as Visipaque. It is a nonionic, iso-osmolar contrast medium primarily utilized for enhancing the visibility of various bodily tissues during radiographic procedures. The development and study of Iodixanol have been driven by several prominent pharmaceutical and research institutions, aimed at achieving a safer and more effective contrast agent. As a drug, it falls under the category of radiographic contrast media and is indicated for use in computed tomography (CT) scans, angiography, and other radiological imaging techniques. Research into Iodixanol has shown that it offers significant benefits over older contrast agents, particularly in terms of safety and patient tolerance.

The mechanism of action of Iodixanol revolves around its ability to enhance the contrast of structures in imaging studies. As a contrast agent, Iodixanol contains iodine, which has high atomic number and electron density, thus absorbing X-rays more effectively than surrounding tissues. When administered into the body, Iodixanol increases the attenuation of X-rays in the targeted area, enhancing the radiographic contrast and allowing for clearer, more detailed images. This is particularly useful in detecting and diagnosing conditions such as vascular diseases, tumors, and organ abnormalities. The iso-osmolarity of Iodixanol, meaning it has the same osmolarity as blood, minimizes the risk of adverse reactions compared to hyperosmolar contrast agents, making it a preferable choice, especially for patients with compromised kidney function or those at high risk of contrast-induced nephropathy.

Administering Iodixanol involves various methods depending on the diagnostic requirements. It can be delivered intravenously, intra-arterially, or intrathecally, with the route of administration chosen based on the specific type of imaging procedure. For instance, intravenous administration is commonly used for CT scans, while intra-arterial may be preferred for angiography. The onset of action of Iodixanol is rapid, typically occurring within seconds to minutes after administration, as it quickly disperses through the bloodstream to the targeted tissues. The dosage and volume of Iodixanol used depend on the patient's age, weight, health status, and the specific diagnostic requirement. Proper hydration before and after the procedure is often recommended to facilitate the clearance of the contrast agent from the body and reduce the risk of nephrotoxicity.

Despite its safety profile, Iodixanol can cause side effects, although they are generally mild and transient. Common side effects include nausea, vomiting, headache, dizziness, and a warm or flushing sensation. In rare cases, more severe reactions can occur, such as anaphylaxis, which requires immediate medical intervention. Iodixanol is contraindicated in patients with a known hypersensitivity to iodinated contrast media or any components of the drug. It should also be used with caution in patients with severe renal impairment, severe cardiovascular disease, or thyroid disorders, as these conditions may increase the risk of adverse reactions. Pre-procedural screening and appropriate pre-medication protocols can help mitigate the risks associated with Iodixanol administration.

Interactions with other drugs are an important consideration when using Iodixanol. Nephrotoxic medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), aminoglycosides, and certain chemotherapeutic agents, can exacerbate the risk of kidney damage when used concurrently with Iodixanol. Additionally, medications affecting thyroid function, like amiodarone, may interact with the iodine in Iodixanol, potentially leading to thyroid dysfunction. Patients on metformin, particularly those with preexisting renal impairment, should be monitored carefully, as the combination with Iodixanol can increase the risk of lactic acidosis. It is crucial to inform healthcare providers of all medications and supplements being taken to appropriately manage potential interactions and ensure the safe use of Iodixanol.